Psilocybin Study Information
Click any of the study name links below to read studies conducted about Magic Mushrooms and Psilocybin. Please take your time to read any studies of interest to form your own educated opinion on the usage and consumption of psychedelic substances.
All Information, images, and links provided on this page are for educational purposes only.
National Institute of Health (NIH) Studies
- National Institute of Drug Abuse-Psilocybin (Magic Mushrooms) Overview
- "The mushrooms have a long history of use in traditional ceremonies."
- Analysis of Psilocybin-Assisted Therapy in Medicine: A Narrative Review
- "Psilocybin-containing mushrooms have been consumed by various cultures in many different parts of the world for thousands of years."
- Psilocybin for Mental Health and Addiction: What You Need To Know
- "The legal status in the United States of psychedelic drugs including psilocybin continues to evolve."
- Potential Therapeutic Effects of Psilocybin: A Systematic Review
- “Treatments using hallucinogenics may offer new vistas on pressing issues with present CNS medications. “
- Clinical potential of psilocybin as a treatment for mental health conditions
- “Based on the studies presented, it appears psilocybin may have some efficacy as an alternative agent to manage mental health conditions.”
- Neural mechanisms underlying psilocybin’s therapeutic potential – the need for preclinical in vivo electrophysiology
- “Psilocybin has shown great potential for treating psychiatric disorders, especially severe depression and anxiety-related conditions.”
- National Institutes of Health (NIH) psilocybin research speaker series: State of the science, regulatory and policy landscape, research gaps, and opportunities
- “The U.S. National Institutes of Health (NIH) convened a seminal first ever psychedelic drug substance-focused speaker series, from April 22 to June 10, 2021”
- NIH: How psychedelic drugs alter the brain
- “In ongoing experimental research, a single psilocybin dose under controlled conditions is showing promise for relieving mental health symptoms such as depression.”
- The Therapeutic Potential of Psilocybin
- “The mushroom extract, psilocybin has historically been used as a psychedelic agent for religious and spiritual ceremonies, as well as a therapeutic option for neuropsychiatric conditions.”
- Psychedelic and Dissociative Drugs
- “Psychedelic and dissociative drugs can temporarily alter a person’s mood, thoughts, and perceptions."
- NIH: Psychedelic and Dissociative Drugs
- “Psychedelic and dissociative drugs can temporarily alter a person’s mood, thoughts, and perceptions.”
- Exploratory Controlled Study of the Migraine-Suppressing Effects of Psilocybin
- "While anecdotal evidence suggests that select 5-hydroxytryptamine 2A (5-HT2A) receptor ligands, including psilocybin, may have long-lasting therapeutic effects after limited dosing in headache disorders"
- Self-administration of Psilocybin for the Acute Treatment of Migraine: A Case Report
- The case of a 33-year-old male patient with a history of migraines
Medical Establishment Psilocybin Studies
- Johns Hopkins: Psychedelics Research and Psilocybin Therapy
- “Previous studies by Johns Hopkins Medicine researchers showed that psychedelic treatment with psilocybin relieved major depressive disorder symptoms in adults for up to a month.”
- Johns Hopkins: Medicine Receives First Federal Grant for Psychedelic Treatment Research in 50 years
- "Johns Hopkins Medicine was awarded a grant from the National Institutes of Health (NIH) to explore the potential impacts of psilocybin on tobacco addiction. “
- WashU Medicine: Psilocybin generates psychedelic experience by disrupting brain network
- “Study advances efforts to harness drug's mind-altering power to treat mental illness”
- American Psychological Association (APA): The emergence of psychedelics as medicine
- “An estimated 40%–60% of people with posttraumatic stress disorder (PTSD) do not respond to the selective serotonin reuptake inhibitors (SSRIs)”
- Medical News Today: Psilocybin (magic mushrooms): What it is, effects and risks
- “The effects of psilocybin vary between people. Factors such as the user’s mental state, personality, and immediate environment may affect their response.”
- UCDAVIS Health: New tool tracks how psychedelics affect neurons in the brain
- “Researchers at UC Davis have developed a rapid, noninvasive tool to track the neurons and biomolecules activated in the brain by psychedelic drugs. “
- UCDAVIS Health: Top psychedelic researchers featured in new video series
- "Psychedelic drugs like psilocybin and ketamine offer promise for treating some mental health conditions"
- Massachusetts General Hospital: Center for the Neuroscience of Psychedelics
- “The Center seeks to understand how psychedelics enhance the brain’s capacity for change, to optimize current treatments and create new treatments for mental illness, and to make the term “treatment resistant” obsolete.”
- Florida State University: The Varieties of Psychedelic Law
- “Scientists are researching the therapeutic properties of these substances, and mounting evidence supports their ability to treat a variety of mental health conditions.”
- Yale School of Medicine: Revived interest in psychedelic therapies
- “As interest resurges in the therapeutic potentials of psychedelic drugs such as psilocybin, made from the active ingredient in so-called magic mushrooms, the Yale Program for Psychedelic Science has been at the forefront of studying these promising new therapies for treating mental illness.”
- Yale Research on Psychedelics Gives Hope to Headache Disorder Community
- Most modern research has focused on therapeutic effects in cluster headache, a severe condition also known as “suicide headache,”
- New England Journal of Medicine: The Promise and Perils of Psychedelics — ITT Episode 3
- “In this episode of “Intention to Treat,” a study participant and a long-time investigator of hallucinogenic drugs for psychiatric conditions illuminate the effects of psilocybin in patients with depression.”
- University of Mississippi: The Past, Present and Future of Psychedelics
- “a systematic literature review that will articulate the need for psychedelics as a treatment for several mental illnesses and ailments.”
- American Migraine Foundation: Can Psilocybin Treat Cluster Headache?
- People with cluster headache have been using psilocybin mushrooms to treat their symptoms for many years.
Around the Web
- Nature.com: Psilocybin desynchronizes the human brain
- “A single dose of psilocybin, a psychedelic that acutely causes distortions of space–time perception and ego dissolution, produces rapid and persistent therapeutic effects in human clinical trials”
- Science Direct: Diversity, biology, and history of psilocybin-containing fungi: Suggestions for research and technological development
- “Therapeutic us of psilocybin has become a focus of recent international research, with preliminary data showing promise to address a range of treatment-resistant mental health conditions.”
- Cell.com-Neuron: Psilocybin induces rapid and persistent growth of dendritic spines in frontal cortex in vivo
- “Psilocybin is a serotonergic psychedelic with untapped therapeutic potential. There are hints that the use of psychedelics can produce neural adaptations, although the extent and timescale of the impact in a mammalian brain are unknown.”
- Psychiatrist.com: Modern Psychedelic Microdosing Research on Mental Health: A Systematic Review
- “The review revealed that microdosing psychedelics, such as lysergic acid diethylamide and psilocybin, showed potential benefits on mental health.”
- Discover Magazine: Psilocybin Use Increases in the U.S. for Those with Chronic and Mental Health Conditions
- “After Denver decriminalized psilocybin in 2019, other cities and states followed suit, although it is not accessible in every part of the country.”
- verywellmind: What Is Psilocybin Therapy?
- “Also known as psilocybin-assisted therapy, psilocybin therapy involves the use of a psychedelic compound that is native to a specific type of mushroom in a psychotherapeutic setting.”
- CNN: Severe depression eased by single dose of synthetic ‘magic mushroom’
- “A single dose of a synthetic version of the mind-altering component of magic mushrooms, psilocybin, improved depression in people with a treatment-resistant form of the disease, a new study found.”
- Sage Journals: 2019: A year of expansion in psychedelic research, industry, and deregulation
- “Public and scientific interest into psychedelic drugs has grown steadily over much of the last two decades, before an exponential increase in recent years. “
- Drugfree.org: PSILOCYBIN (Shrooms)
- “Psilocybin has been used in clinical trials to treat mental health problems such as depression, anxiety, post-traumatic stress disorder and obsessive-compulsive disorder. In addition, trials have focused on the treatment of nicotine (tobacco) and alcohol use disorders.”
- Alzheimers.gov: Psilocybin for Depression in People With Mild Cognitive Impairment or Early Alzheimer's Disease
- This pilot study will evaluate whether psilocybin, provided in a supervised environment, reduces “depression and improves the quality of life in people with mild cognitive impairment or early-stage Alzheimer's disease.”
- Science.org: Psychedelic-inspired drugs could relieve depression without causing hallucinations
- “The results, they say, pave the way to developing psychedelic-like drugs that could treat depression without hallucinations.”
- ResearchGate: Could psychedelic drugs have a role in the treatment of schizophrenia? Rationale and strategy for safe implementation
- "Could psychedelic drugs have a role in the treatment of schizophrenia?"
- NIHR: Magic mushroom compound performs at least as well as leading antidepressant medication in small study
- “The results, published today in the New England Journal of Medicine, show that while depression scores were reduced in both groups, the reductions occurred more quickly in the psilocybin group and were greater in magnitude.”
- National Institute for Health Research (NIHR): Psilocybin-assisted therapy for depression
- YouTube Video
- “Our success has led to further plans for psilocybin therapy to be trialed in those with post-traumatic stress disorder (PTSD). “
- Exploratory Controlled Study of the Migraine-Suppressing Effects of Psilocybin
- "Reductions from baseline were significantly greater after psilocybin compared to placebo in weekly migraine attacks"
- Medical News Today: What to know about psilocybin and migraine
- "Small research studies indicate that it may help prevent migraine."
- Psilocybin pulse regimen reduces cluster headache attack frequency in the blinded extension phase of a randomized controlled trial
- "Reports describe reduced cluster attack burden after a 3-dose pulse of psilocybin."
- Single Dose of Psilocybin Reduces Migraines for at Least 2 Weeks
- New research from Yale finds that a single low dose of psilocybin reduces the frequency of migraine headaches for 2 weeks.
- Healio.com: Psilocybin use effective in treating cluster headaches, migraines
- “Compared to a placebo, psilocybin reduced the number of migraines by about 15%,” Schindler said. “Pain was also reduced. There was also a reduction in the functional impairment during migraine attack.”
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